A girl Two Leaf knows comes to town to take care of some business. Later she's killed with Two Leaf's knife and he has scratches on his face that matches her hands. Dan thinks he's being set up but Nelson has no choice but to take him in. Later a television reporter is trying to paint Two Leaf as a danger to society. Upon hearing this he breaks out of jail.

Dan comes looking for Roth and finds a man named Rodmore in charge. So Dan tries to find Roth to find out what's going on but he appears to have vanished. So he tries to find out why Roth turned control of the company to Rodmore. At the same time someone is following Dan.

Sister Bridget Callahan hires Dan to find drug addict Jimmy Porter and recover the Cross of Casseras, which Jimmy stole from her New Mexico mission to sell to someone else. But she won't reveal Jimmy's name, thereby complicating Dan's task.

Dan is hired by a man to look for his daughter who is pregnant. While Dan tries to find her someone is following him. When he eventually finds her, she calls her father to come but when he arrive she claims he is not her father. That's when he pulls a gun.

Dan's hired by a designer who's at the hotel to unveil her new line. It seems some of her models are being terrorized and one of them is Dan's ex. While investigating, the men who are terrorizing them are putting their plan in motion. One of the men who fears that Dan's ex who saw him commit one of their acts against them might identify him kills her which makes things more personal for Dan.

When a singer who's suppose to perform at the hotel is sexually assaulted, she asks for private investigator. So the manager calls Dan. She wants Dan to keep it quiet out of fear that it could ruin her career and life. So Dan asks Nelson to make it quiet. He then goes to a rape counselor who tells Dan that her attacker will do it again. What Dan doesn't know is that her attacker could be closer to her than he thinks

Victor Durand once ran a bogus clinic before Dan sent him to prison. Now Durand takes revenge by stealing a toxin, infecting Dan with it, and taunting him, while Dan and his doctors frantically search for a cure to keep Dan alive.

When pimp Luke Manning is gunned down in his home, women's rights activist Virginia Marshall is accused, hires Dan, and tells him she couldn't have killed Luke because her gun was stolen two weeks earlier.

When the casino takes in more chips than they dispensed, there's concern that someone has stolen the hotel's chips. So Dan talks to Clay Summer, who makes the chips and swears there's no way to take a chip out of the plant. When Clay's innocence is questioned, Dan sets out to prove his innocence. Clay's son Brad, who faked his death, is behind it and is working with plant employee Eddie Stolvak. When Eddie gets nervous, Brad kills Eddie and frames Dan.

When a friend of Dan's is killed he sets out to find out who killed him. At the same time another friend, Justin Marsh a former race car driver is in town for a car show. Dan notices a woman following Marsh so he asks her what she wants she tells him to back off. Later someone takes a shot at Dan. He goes to the woman and sees Nelson with her and she tells him that Matsh may have been involved with his friend's death. She reveals that Marsh after his career ending accident was approached by man who convinced him to aid him with illegal businesses. His friend may have been involved with Marsh's activities and wanted out which is why he was killed. Dan doesn't believe it but when he checks Marsh out he changes his mind.

When a friend of Dan's who's also a P.I. is killed, his girlfriend asks him to look into it. At the same time, there's a P.I. convention going on at the hotel and some other P.I.s are getting killed. A female P.I. knows something but she's not willing to share it. When an attempt is made on her, she reveals that she and other P.I.'s were hired to solve a case that's been unsolved for years.

Binzer goes to see Paula Conway a hypnotist for a little self improvement. But what he doesn't know is she has been hired by some malefactors to turn him into their private assassin. When Tanna notices Binzer has been missing for several days he looks for him. While looking for Binzer, Tanna runs into Jamie Randall, an old friend, who is a reporter doing research on point shaving at college basketball games. It seems the men who hired Paula are the ones behind the point shaving and Binzer being hypnotized to kill Jamie and a player whom they approached who turned them down, plus collateral damage and anyone who gets in Binzer's way. (The trigger word that will turn Binzer lethal is "superstar".)

Mitch Costigian, Dan's Army buddy who's been away for sometime returns to town to perform at the hotel. He's also a newlywed. When he and Dan go to the hotel, his wife stays behind to fix things at the house. Later someone plants an explosive and blows the house up. Mitch is devastated. Later Dan learns that the explosive used is similar to what was used in Vietnam. So Dan thinks there may be a link to their time in Vietnam to what happened to Mitch's wife. Mitch is on a mission to find the one who killed his wife.

Bea meets a guy while on vacation and gets engaged. She brings him to Vegas to meet everyone. When Tanna sees him he recognizes him as Miles Glover (now calling himself "Drew Marley"), the man who stole away a girl Tanna was dating years earlier. Later, she died mysteriously and he walked away with her money. Unfortunately, Dan's word is not enough so he tries to get information and find the sister of the dead girl who knew the man back then. Meanwhile, Glover/Marley tries to ensure that Tanna does not spoil his plans.

Dan is targeted by a man who's trying to get a gaming license because Dan has a videotape that shows him consorting with criminals. He sends a professional hit man to get Dan but he misses. He abducts Mitch Costigian, Dan's friend and holds him to get Dan to turn the tape over to him.

A trio of beauties become suspiciously good at the baccarat table. Another player at the table, Everett Mason, wants in on their secret. As it turns out, so does aging French detective Nicholas Rambeau.

Roth is planning to put a hotel casino in Toronto and to help him with financing, he organizes a consortium of businessmen. But they're having a hard time on deciding who should be in charge. Roth wants Paul Bracken, one of his people and Dan's brother in law to be the one. But one of the members of the consortium, Mel Brandon, wants to be the one in charge. So sets out to make Paul undesirable by going after Dan and everyone around him, Bea and Binzer.

When someone with a grudge against Nelson goes after his family, he tries to handle it on his own. But Dan insists on helping.

A headlining, talented, versatile illusionist and female impersonator is receiving bizarre death threats. His manager says he's just over reacting. When he reaches out to Dan Tanna for help, Dan begins, also, to get death threats.

A cop from San Francisco who's a friend of Dan's comes to Vegas. It seems that someone is targeting cops, sending them messages telling them when they will be killed usually with a number in it. The man follows the cop and kills him in front of Dan. Dan notices two women when his friend was killed. Dan decides to go to San Francisco and is shunned by the police department but decides to investigate nonetheless and sees the women and later learns that they're cops who were sent by his friend's boss to keep an eye on him. Their boss wants Dan to leave but upon learning that he made some discoveries decides to let Dan stay.

Some men try to rob the hotel but something goes wrong and they take some the showgirls hostage and Bea who was there watching them was also taken. They hold up in a room where the cops can't get to them. The leader then demands 5 million dollars or else he'll kill one of the girls every hour. And to prove he's serious, he kills one and sends her down the elevator. Dan tries to find a way to save the girls and Bea.

An old friend of Dan's who owns a Italian restaurant, is poisoned during a wedding celebration when a bad guy adds drugs to his silver wine goblet. Until Dan investigates, an old vendetta is blamed and the goblet is considered cursed.